Martino and colleagues explained in their background information that evidence suggests the heart repairs or remodels itself primarily during sleep. But while studies have been done to show that timing of heart medication can alter diurnal patterns of blood pressure in patients with high blood pressure , little is known about how the timing of such medication affects heart remodeling.
The researchers decided to test ACE inhibitors because these drugs inhibit the activity of a natural hormone involved in heart repair. The levels of this hormone are highest at night, causing the heart to enlarge and increasing the risk of cardiac damage in heart patients. The mice were then split into two groups: one was injected with ACE inhibitor and the other with placebo. Each group was further subdivided into two sets of mice: one set had the injection during wake time, and the other at sleep time.
All groups were treated for 8 weeks, starting 1 week after surgery. The results showed that the mice that received ACE inhibitor at sleep time had improved heart function and their hearts were less enlarged compared to the mice that had received the drug at wake time and the mice given the placebo.
These beneficial effects of the ACE inhibitor also correlated with diurnal changes in genetic expression of ACE in the heart. However, the ACE inhibitor led to similar drops in blood pressure at both sleep and wake time, suggesting that the time of day differences were not due to blood pressure changes, wrote the authors.
They said the findings add weight to the idea that the heart and its blood vessels remodel during sleep time, and also shows the importance of diurnal timing for some cardiovascular drugs. Learn what can affect them and how to take an accurate…. Blood pressure can be different in each arm. While a slight difference can be fine, a greater difference may be a sign of a condition that needs….
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ACE inhibitors are medicines that were first designed to treat high blood pressure. They are safe and have few side effects. There are several different brand names. ACE inhibitors are safe for most people, but not for everyone. The following are people who shouldn't take ACE inhibitors:.
Pregnant women. An ACE inhibitor might hurt the baby during the last six months of pregnancy. If you were already taking an ACE inhibitor and stop taking it during the first three months of pregnancy, the risk to your baby is very low.
Your doctor can give you other medicines that are safe to use during pregnancy. People with severe kidney failure. If you have this problem, an ACE inhibitor may not be safe for your kidneys. Your kidney function would have to be closely watched.
Your doctor will know if you have this problem. People who have ever had a severe allergic reaction that caused their tongue and lips to swell, even if it was from a bee sting, should not take ACE inhibitors. If you have this reaction to the medicine, go to the hospital right away. Dry cough can occur in about one in 10 people. Sometimes this even happens after they have been taking the medicine for months.
If you have a cough and it makes you too uncomfortable, talk to your doctor. You might be able to try another kind of ACE inhibitor. A different brand of this medicine might not make you cough. Dizziness can happen with the first or second dose.
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